After 
a disappointing season the Arizona Diamondbacks made a managerial change replacing Bob Melvin with AJ Hinch.
On April 5, 2010 the Diamondbacks would host the San Diego Padres at Chase Field in Phoenix AZ.
With right-handed pitcher Brandon Webb still recuperating from an injury right-handed pitcher Dan Haren would take the mound for the Arizona Diamondbacks.
The Opening Day line-up featured six changes from the previous season.
Justin Upton was back in the lineup playing right field hoping to overcome an injury plagued season a year ago. Adam LaRoche was now manning first base. Miguel Montero was the new starting catcher. Kelly Johnson was the new second baseman. The final change was Haren who was the starting pitcher
For the seventh time in franchise history the Diamondbacks won their season opener. The final score Diamondbacks 6 - Padres 3 in front of 49,192.
| 2010 | ||
| Order | Name | Position |
| 1. | Conor Jackson | LF |
| 2. | Stephen Drew | SS |
| 3. | Justin Upton | RF |
| 4. | Adam LaRoche | 1B |
| 5. | Mark Reynolds | 3B |
| 6. | Miguel Montero | C |
| 7. | Chris Young | CF |
| 8. | Kelly Johnson | 2B |
| 9. | Dan Haren | RHP |
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