With 
the team underperforming the Diamondbacks made a general manager and managerial change after the 2010 season replacing AJ Hinch with Kirk Gibson as manager.
On April 1, 2011 the Diamondbacks would visit the Colorado Rockies at Coors Field in Denver CO.
Right-handed pitcher Ian Kennedy would take the mound for the Arizona Diamondbacks.
The Opening Day line-up featured five changes from the previous season.
Willie Bloomquist would get the start at shortstop for the injured Stephen Drew. Juan Miranda would be the starting first baseman. Mevin Mora would play third base. Gerardo Parra made his first Opening Day start in left field. Ian Kennedy would get his first Opening Day start of his career.
For the eighth time in franchise history and the fifth consecutive year the Diamondbacks won their season opener. The final score Diamondbacks 7 - Rockies 6 in 11 innings in front of 49,374.
| 2011 | ||
| Order | Name | Position |
| 1. | Willie Bloomquist | SS |
| 2. | Kelly Johnson | 2B |
| 3. | Justin Upton | RF |
| 4. | Chris Young | CF |
| 5. | Juan Miranda | 1B |
| 6. | Melvin Mora | 3B |
| 7. | Miguel Montero | C |
| 8. | Gerardo Parra | LF |
| 9. | Ian Kennedy | RHP |
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