For the Arizona Diamondbacks the 2021 regular season began on April 1, 2021 with a three-game series against the San Diego Padres at Petco Park. This was the 6th season that the Diamondbacks had opened on the road. The season featured visits to Oakland, Texas, Seattle, and Houston to face the American League West teams. American League opponents appearing at Chase Field included the Oakland Athletics, Texas Rangers, Seattle Mariners and Los Angeles Angels. The season concluded with a 3-game series with the Colorado Rockies at Chase Field on October 1 through October 3.
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