The following transactions were recorded by the Arizona Diamondbacks for the calendar year 2005.
| December | |
| Date | Description |
| 12/30/2005 | Signed OF Eric Byrnes, who had been with the Orioles, to a one-year contract. |
| 12/27/2005 | Acquired RHP Miguel Batista and 2B Orlando Hudson from the Blue Jays in exchange for 3B Troy Glaus and SS Sergio Santos. |
| 12/20/2005 | Acquired RHP Orlando Hernandez, RHP Luis Vizcaino and OF Chris Young from the White Sox in exchange for Javier Vazquez and cash considerations. |
| 12/13/2005 | Signed free agent RHP Jason Grimsley to a one-year contract. |
| 12/12/2005 | Signed INF Damion Easley to a one-year contract. |
| 12/07/2005 | Declined to offer arbitration to SS Royce Clayton and LHP Shawn Estes. Acquired C Johnny Estrada from the Atlanta Braves in exchange for RHPs Lance Cormier and Oscar Villarreal. |
| November | |
| Date | Description |
| 11/18/2005 | Purchased the contracts of RHP Mike Schultz, LHP Doug Slaten and C Miguel Montero from Double-A Tennessee, and INF Sergio Santos from Triple-A Tucson; sent INF Jerry Gil, OF Marland Williams and LHP Bill Murphy outright to Triple-A Tucson. |
| October | |
| Date | Description |
| 10/14/2005 | Sent OF Quinton McCracken outright to Triple-A Tucson; McCracken refused the assignment and is now a free agent. Sent C Kelly Stinnett outright to Triple-A Tucson; Stinnett refused the assignment and is now a free agent. |
| September | |
| Date | Description |
| 09/09/2005 | Activated LHP Shawn Estes from the 60-day disabled list; Recalled INF Jerry Gil from Double-A Tennessee and placed him on the 60-day disabled list. |
| 09/06/2005 | Recalled RHP Greg Aquino from Triple-A Tucson. |
| 09/04/2005 | Recalled RHP Dustin Nippert from Double-A Tennessee. |
| 09/02/2005 | Recalled OF Scott Hairston from Triple-A Tucson and placed on the 60-day disabled list; Recalled RHP Brian Bruney and C Koyie Hill from Triple-A Tucson; Purchased the contract of INF Andy Green from Triple-A Tucson; Activated RHP Oscar Villarreal off the 60-day disabled list. |
| August | |
| Date | Description |
| 08/25/2005 | Recalled RHP Jason Bulger from Triple-A Tucson and optioned RHP Greg Aquino to Triple-A Tucson. |
| 08/19/2005 | Recalled RHP Brandon Medders from Triple-A Tucson and optioned RHP Brian Bruney to Triple-A Tucson. |
| 08/17/2005 | Outrighted RHP Mike Koplove to Triple-A Tucson. |
| 08/13/2005 | Optioned C Koyie Hill to Triple-A Tucson; activated RHP Brandon Lyon from the 60-day disabled list and RHP Russ Ortiz from the 15-day disabled list; transferred LHP Shawn Estes from the 15-day to 60-day disabled list; optioned RHP Mike Koplove to Triple-A Tucson. |
| 08/09/2005 | Activated C Kelly Stinnett from the 15-day disabled list and optioned LHP Michael Gosling to Triple-A Tucson. |
| 08/05/2005 | Signed 1B Tony Clark to a two-year contract extension. |
| July | |
| Date | Description |
| 07/31/2005 | Acquired LHP Buddy Groom from the Yankees for a player to be named later. Acquired RHP Kyle Bono and INF Kenny Perez from the Red Sox for OF Jose Cruz Jr. and cash. |
| 07/27/2005 | Purchased the contract of 1B/OF Conor Jackson from Triple-A Tucson and designated OF Jose Cruz Jr. for assignment. |
| 07/21/2005 | Acquired RHP Tim Worrell and cash considerations from the Phillies for INF Matt Kata. |
| 07/19/2005 | Placed C Kelly Stinnett on the 15-day disabled list with a left wrist sprain and recalled C Koyie Hill from Triple-A Tucson. |
| 07/07/2005 | Placed LHP Shawn Estes on the 15-day disabled list, retroactive to July 6, with a stress reaction of his left ankle and recalled RHP Brandon Medders from Triple-A Tucson. |
| 07/05/2005 | Designated LHP Javier Lopez for assignment and purchased the contract of LHP Armando Almanza from Triple-A Tucson; Signed RHP Vladimir Nunez to a Minor League contract and assigned him to Triple-A Tucson. |
| 07/02/2005 | Recalled LHP Michael Gosling from Triple-A Tucson and optioned RHP Brandon Medders to Triple-A Tucson. |
| June | |
| Date | Description |
| 06/29/2005 | Activated OF Luis Gonzalez from the bereavement list and optioned INF Matt Kata to Triple-A Tucson. |
| 06/28/2005 | Activated OF Luis Terrero from 15-day disabled list and optioned OF Scott Hairston to Triple-A Tucson. |
| 06/25/2005 | Placed OF Luis Gonzalez on the bereavement list. Recalled IF Matt Kata from Triple-A Tucscon. |
| 06/23/2005 | Assigned RHP Matt Herges to Triple-A Tucson after he cleared waivers. |
| 06/18/2005 | Recalled RHP Mike Koplove and purchased the contract of RHP Brandon Medders from Triple-A Tucson; designated RHP Matt Herges for assignment. Placed RHP Russ Ortiz on the 15-day disabled list with a strained rib cage. |
| 06/12/2005 | Transferred RHP Brandon Lyon from the 15-day to the 60-day disabled list and activated RHP Greg Aquino from the 60-day disabled list; optioned RHP Edgar Gonzalez to Triple-A Tucson. |
| 06/09/2005 | Optioned RHP Mike Koplove to Triple-A Tucson and recalled RHP Edgar Gonzalez from Triple-A Tucson. |
| 06/08/2005 | Placed OF Luis Terrero on the 15-day disabled list with a left groin strain and recalled OF Scott Hairston from Triple-A Tucson. |
| 06/04/2005 | Designated RHP Kerry Ligtenberg for assignment and optioned INF Matt Kata to Triple-A Tucson; Sent RHP Justin Wechsler outright to Double-A Tennessee and transferred SS Jerry Gil from the 15-day disabled list to the 60-day disabled list. |
| 06/03/2005 | Acquired RHP Matt Herges from the San Francisco Giants in exchange for OF Doug DeVore; Claimed RHP Claudio Vargas off waivers from the Nationals. |
| May | |
| Date | Description |
| 05/28/2005 | Optioned C Koyie Hill to Triple-A Tucson and purchased the contract of C Kelly Stinnett from Triple-A Tucson; Transferred RHP Oscar Villarreal from 15-day to 60-day disabled list. |
| 05/11/2005 | Sent LHP Randy Choate outright to Triple-A Tucson. |
| 05/09/2005 | Optioned INF Matt Kata to Triple-A Tucson and activated OF Jose Cruz Jr. from the 15-day disabled list. |
| 05/05/2005 | Purchased the contract of RHP Kerry Ligtenberg from Triple-A Tucson; Designated LHP Randy Choate for assignment. |
| 05/04/2005 | Released nonroster LHP Darren Oliver from Triple-A Tucson. |
| 05/02/2005 | Optioned OF Scott Hairston to Triple-A Tucson and activated Jose Valverde from the 15-day disabled list. |
| April | |
| Date | Description |
| 04/24/2005 | Recalled LHP Javier Lopez from Triple-A Tucson and optioned LHP Mike Gosling to Triple-A Tucson. |
| 04/20/2005 | Signed LHP Armando Almanza to a Minor League contract and assigned him to Double-A Tennessee. |
| 04/18/2005 | Announced that RHP Adam Peterson has been claimed off waivers by the Detroit Tigers. |
| 04/16/2005 | Placed OF Jose Cruz Jr. on the 15-day disabled list, retroactive to April 10, with a low back strain; Recalled OF Scott Hairston from Triple-A Tucson. |
| 04/15/2005 | Designated RHP Adam Peterson for assignment. |
| 04/14/2005 | Claimed LHP Javier Lopez off waivers from the Rockies. |
| 04/11/2005 | Placed RHP Oscar Villarreal on the 15-day disabled list and recalled RHP Lance Cormier from Triple-A Tucson. |
| 04/10/2005 | Signed LHP Darren Oliver to a minor league contract; Placed RHP Greg Aquino on the 15-day disabled list, retroactive to April 5, with ulnar nerve irritation. |
| 04/09/2005 | Recalled RHP Oscar Villarreal from Triple-A Tucson. |
| 04/03/2005 | Purchased the contract of OF Quinton McCracken from Triple-A Tucson and designated OF Reggie Abercrombie for assignment. |
| 04/02/2005 | Placed RHP Jose Valverde on the 15-day disabled list, retroactive to March 25, with an irritated biceps tendon and placed INF Jerry Gil on the 15-day disabled list recovering from March 2005 right knee surgery; Optioned RHP Oscar Villarreal to Triple-A Tucson. |
| March | |
| Date | Description |
| 03/28/2005 | Optioned RHP Lance Cormier and INF Scott Hairston to Triple-A Tucson; Re-assigned LHP Kevin Tolar to minor league camp; Released C Kelly Stinnett. |
| 03/24/2005 | Released RHP Juan Acevedo and RHP Jose Jimenez; Re-assigned OF Carlos Quentin and INF Andy Green to minor league camp. |
| 03/23/2005 | Re-assigned C Craig Ansman and LHP Shane Nance to minor league camp. |
| 03/22/2005 | Re-assigned LHP Jon Cannon and RHP Brandon Medders to minor league camp. |
| 03/18/2005 | Optioned RHP Edgar Gonzalez, RHP Jason Bulger, RHP Adam Peterson, RHP Tony Pena and LHP Bill Murphy to minor league camp. |
| 03/14/2005 | Optioned RHP Justin Wechsler, RHP Dustin Nippert, RHP Enrique Gonzales, OF Reggie Abercrombie, and OF Josh Kroeger; Re-assigned RHP Phil Stockman, RHP Casey Daigle, C Corey Myers, INF Alan Zinter, C Juan Brito, and OF Doug DeVore; Released LHP Donovan Osborne. |
| February | |
| Date | Description |
| 02/18/2005 | Acquired LHP Brad Murray from the White Sox as the PTBN from the Aug. 5, 2004, trade that sent INF Roberto Alomar to Chicago. |
| 02/11/2005 | Signed RHP Juan Acevedo to a minor-league contract with an invitation to Spring Training. |
| 02/06/2005 | Acquired OF Jose Cruz Jr. and cash from the Devil Rays in exchange for LHP Casey Fossum. |
| January | |
| Date | Description |
| 01/28/2005 | Designated C Robby Hammock for assignment; Re-signed LHP Jon Cannon, RHP Brandon Medders, LHP Shane Nance, C Craig Ansman, C Juan Brito and C Corey Myers to minor league contracts with invitations to Spring Training; Signed LHP Kevin Tolar to a minor league contract with an invitation to Spring Training; Invited minor league OF Conor Jackson to Spring Training. |
| 01/27/2005 | Agreed to terms with RHP Mike Koplove on a two-year contract. |
| 01/24/2005 | Signed 1B Tony Clark to a one-year contract. |
| 01/19/2005 | Signed RHP Jose Jimenez to a minor league contract with an invitation to Spring Training. |
| 01/18/2005 | Agreed to terms with RHP Brandon Lyon on a one-year contract. |
| 01/17/2005 | Agreed to terms with LHP Randy Choate on a two-year contract. |
| 01/13/2005 | Designated RHP Casey Daigle for assignment. |
| 01/12/2005 | Traded INF Shea Hillenbrand to the Blue Jays for RHP Adam Peterson. Signed LHP Shawn Estes to a one-year contract. |
| 01/11/2005 | Acquired OF Shawn Green from the Dodgers in exchange for C Dioner Navarro, RHP Danny Muegge, RHP Beltran Perez and RHP William Juarez. Acquired RHP Javier Vazquez, LHP Brad Halsey, C Dioner Navarro and cash from the Yankees in exchange for LHP Randy Johnson. |
| 01/10/2005 | Traded LHP Stephen Randolph to the Chicago Cubs in exchange for a player to be named later. |
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